Endocrine Abstracts

The ketogenic diet (KD) has been extensively studied as a potential therapeutic approach for various conditions, including Polycystic Ovary Syndrome (PCOS) in women. We describe a 29-year-old overweight woman with PCOS. Clinically, she presented with hirsutism, acne, and pink stretch marks in the hip and abdomen areas, no significant menstrual cycle disturbances were reported. Patient underwent a 12-week KD regimen. Initially, her body mass index (BMI) was 33.5, with a weight ...

The therapy of hyperprolactinemia with dopamine agonists (DAs) is highly effective in the majority of cases (1). However, some patients fail to achieve normal prolactin levels and develop drug resistance towards prescribed medicine. This case study describes a medical history of The Georgian National Institute of Endocrinology patient, with a drug-resistant hyperprolactinemia and inability to conceive. The patient’s MRI scan result has not indicated incidence of pr...

Even in the presence of normally circulating androgens, the imbalance between estrogen and androgen in males between the prepubertal and pubertal periods may have an impact on male reproductive function. While there are many variables that affect how each person reaches puberty at different times, boys who are becoming more obese have higher aromatase activity. This enzyme turns testosterone into estradiol permanently, which lowers testosterone levels and raises estrogen level...

Introduction: Puberty is a crucial period, marking the transition from childhood to adulthood with significant physical and psychological changes. (1) In girls, when puberty begins before the age of eight, it is considered precocious. (2) While multiple factors influence individual differences in pubertal timing, the interactions between hormones and nutrition during critical growth periods, like puberty, are crucial. (3) Girls with a higher BMI experienced early menarche comp...

Overview: Numerous epidemiological studies have demonstrated that low testosterone levels are linked to poor life quality and sexual quality, and that hypoestrogenic hypogonadism in obese male patients is connected with and predicts the development of metabolic syndrome and type 2 diabetes in the future. The purpose of the study was to demonstrate how aromatase inhibitors affected anthropometric traits, HOMA-IR, blood pressure, glycosylated hemoglobin level, and dyslipidemia i...